A randomised placebo-controlled trial to determine the effect of iron supplementation on pregnancy outcome in pregnant women with haemoglobin > or = 13.2 g/dl
- PMID: 17516958
- DOI: 10.1111/j.1471-0528.2007.01325.x
A randomised placebo-controlled trial to determine the effect of iron supplementation on pregnancy outcome in pregnant women with haemoglobin > or = 13.2 g/dl
Erratum in
- BJOG. 2007 Oct;114(10):1311. Dosage error in published abstract; MEDLINE/PubMed abstract corrected
Abstract
Objective: To study the effect of iron supplementation on pregnancy outcome in pregnant women with haemoglobin (Hb) > or = 13.2 g/dl.
Design: A randomised, double-blind, placebo-controlled trial.
Setting: Routine health services.
Population: Seven hundred and twenty-seven pregnant women with Hb > or = 13.2 g/dl in the early stage of the second trimester.
Methods: Each woman took one ferrous sulphate [DOSAGE ERROR CORRECTED] tablet (150 g tablet, containing 50 mg of elemental iron) [DOSAGE ERROR CORRECTED] daily in the case group (n = 370) or placebo in the control group (n = 357) throughout pregnancy.
Main outcome measures: Pregnancy outcome.
Results: While there were no significant differences in demographic and obstetric characteristics between the two groups before any intervention, small-for-gestational-age birth rate and the number of women with hypertension disorder increased significantly in the case group in comparison with the control group (57 [15.7%] versus 36 [10.3%], P = 0.035, 10 [2.7%] versus 3 [8%], P = 0.05, respectively).
Conclusions: Our finding proves that routine iron supplementation in nonanaemic women is not rational and may be harmful.
Comment in
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Unnecessary iron supplementation in pregnancy can be harmful: intergenerational implications.BJOG. 2007 Oct;114(10):1308. doi: 10.1111/j.1471-0528.2007.01451.x. BJOG. 2007. PMID: 17877695 No abstract available.
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Rethinking iron supplementation recommendations in health care.BJOG. 2007 Dec;114(12):1581. doi: 10.1111/j.1471-0528.2007.01532.x. BJOG. 2007. PMID: 17995501 No abstract available.
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Iron, pre-eclampsia and hypoxia-inducible factor.BJOG. 2007 Dec;114(12):1581-2. doi: 10.1111/j.1471-0528.2007.01490.x. BJOG. 2007. PMID: 17995502 No abstract available.
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Iron supplementation in non-anaemic women did not improve pregnancy outcomes and may be harmful to both mother and baby.Evid Based Med. 2008 Feb;13(1):15. doi: 10.1136/ebm.13.1.15. Evid Based Med. 2008. PMID: 18234923 No abstract available.
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Iron supplementation in non-anaemic women did not improve pregnancy outcomes and may be harmful to both mother and baby.Arch Dis Child Educ Pract Ed. 2009 Jun;94(3):94. Arch Dis Child Educ Pract Ed. 2009. PMID: 19460901 No abstract available.
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