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Randomized Controlled Trial
. 2007 Jun;150(6):592-6, 596.e1-5.
doi: 10.1016/j.jpeds.2007.02.012.

Interobserver reliability and accuracy of cranial ultrasound scanning interpretation in premature infants

Susan R Hintz  1 , Thomas Slovis, Dorothy Bulas, Krisa P Van Meurs, Rebecca Perritt, David K Stevenson, W Kenneth Poole, Abhik Das, Rosemary D Higgins; NICHD Neonatal Research Network
Affiliations
Randomized Controlled Trial

Interobserver reliability and accuracy of cranial ultrasound scanning interpretation in premature infants

Susan R Hintz et al. J Pediatr. 2007 Jun.

Abstract

Objective: To assess interobserver reliability between 2 central readers of cranial ultrasound scanning (CUS) and accuracy of local, compared with central, interpretations.

Study design: The study was a retrospective analysis of CUS data from the National Institute of Child Health and Human Development (NICHD) trial of inhaled nitric oxide for premature infants. Interobserver reliability of 2 central readers was assessed with kappa or weighted kappa. Accuracy of local, compared with central, interpretations was assessed by using sensitivity and specificity.

Results: CUS from 326 infants had both central reader and local interpretations. Central reader agreement for grade 3/4 intraventricular hemorrhage (IVH), grade 3/4 IVH or periventricular leukomalacia (PVL), grade of IVH, and degree of ventriculomegaly was very good (kappa = 0.84, 0.81, 0.79, and 0.75, respectively). Agreement was poor for lower grade IVH and for PVL alone. Local interpretations were highly accurate for grade 3/4 IVH or PVL (sensitivity, 87%-90%; specificity, 92%-93%), but sensitivity was poor-to-fair for grade 1/2 IVH (48%-68%) and PVL (20%-44%).

Conclusions: Our findings demonstrate reliability and accuracy of highly unfavorable CUS findings, but suggest caution when interpreting mild to moderate IVH or white matter injury.

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Figures

Figure 1
Figure 1
Central Reader data instrument from the NICHD Neonatal Research Network PiNO Trial
See this image and copyright information in PMC

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