Particulate air pollution, progression, and survival after myocardial infarction

Abstract

Objective: Several studies have examined the effect of particulate pollution (PM) on survival in general populations, but less is known about susceptible groups. Moreover, previous cohort studies have been cross-sectional and subject to confounding by uncontrolled differences between cities.

Design: We investigated whether PM was associated with progression of disease or reduced survival in a study of 196,000 persons from 21 U.S. cities discharged alive following an acute myocardial infarction (MI), using within-city between-year exposure to PM. We constructed city-specific cohorts of survivors of acute MI using Medicare data between 1985 and 1999, and defined three outcomes on follow-up: death, subsequent MI, and a first admission for congestive heart failure (CHF). Yearly averages of PM(10) (particulate matter with aerodynamic diameter < 10 microm) were merged to the individual annual follow-up in each city. We applied Cox's proportional hazard regression model in each city, with adjustment for individual risk factors. In the second stage of the analysis, the city-specific results were combined using a meta-regression.

Results: We found significant associations with a hazard ratio for the sum of the distributed lags of 1.3 [95% confidence interval (CI), 1.2-1.5] for mortality, a hazard ratio of 1.4 (95% CI, 1.2-1.7) for a hospitalization for CHF, and a hazard ratio of 1.4 (95% CI, 1.1-1.8) for a new hospitalization for MI per 10 microg/m(3) PM(10).

Conclusions: This is the first long-term study showing a significant association between particle exposure and adverse post-MI outcomes in persons who survived an MI.

Figure 1

Effect modification by sex and age group in the three survival analyses, in which failure is defined as death, a subsequent MI, or CHF. The effects were computed by stratified analysis for each sex or age group (65–75 years or > 75 years) and PM₁₀ averaged over 3 years. Effects are computed for 10 μg/m³ PM₁₀.