[Clinical features and pathology of Resochin - implantation in the cornea (author's transl)]

Abstract

The long-term therapy with Resochin leads in a proportion of cases to reversible changes in the cornea. There is no direct relationship between the total dose used and the keratopathy. Point-like "Infiltrations" can be identified histologically in the cytoplasm of the epithelium and also vacuolised cells and cell necrosis, mainly in the surface epithelial layers. Under the electron microscope one can see, alongside intact cells, cells with multiple lyosomal inclusions, surrounded by a membrane, and myelin figures. The changes described are probably to be seen as after-effects of the influence of the drug.