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Clinical Trial
. 2007 Jul;9(3):319-25.
doi: 10.1215/15228517-2007-016. Epub 2007 May 23.

Incidence of gliomas by anatomic location

Suvi Larjavaara  1 , Riitta Mäntylä, Tiina Salminen, Hannu Haapasalo, Jani Raitanen, Juha Jääskeläinen, Anssi Auvinen
Affiliations
Clinical Trial

Incidence of gliomas by anatomic location

Suvi Larjavaara et al. Neuro Oncol. 2007 Jul.

Abstract

The anatomic location of a glioma influences prognosis and treatment options. The aim of our study was to describe the distribution of gliomas in different anatomic areas of the brain. A representative population-based sample of 331 adults with glioma was used for preliminary analyses. The anatomic locations for 89 patients from a single center were analyzed in more detail from radiologic imaging and recorded on a three-dimensional 1 x 1 x 1-cm grid. The age-standardized incidence rate of gliomas was 4.7 per 100,000 person-years. The most frequent subtypes were glioblastoma (47%) and grade II-III astrocytoma (23%), followed by oligodendroglioma and mixed glioma. The gliomas were located in the frontal lobe in 40% of the cases, temporal in 29%, parietal in 14%, and occipital lobe in 3%, with 14% in the deeper structures. The difference in distribution between lobes remained after adjustment for their tissue volume: the tumor:volume ratio was 4.5 for frontal, 4.8 for temporal, and 2.3 for parietal relative to the occipital lobe. The area with the densest occurrence was the anterior subcortical brain. Statistically significant spatial clustering was found in the three-dimensional analysis. No differences in location were found among glioblastoma, diffuse astrocytoma, and oligodendroglioma. Our results demonstrate considerable heterogeneity in the anatomic distribution of gliomas within the brain.

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Figures

Fig. 1
Fig. 1
The anatomic site distribution of gliomas in an axial projection of the brain (anterior at top). The colors represent the number of gliomas in each 1 × 1–cm square, with smoothing based on adjacent squares. The inset shows the section plane.
Fig. 2
Fig. 2
The anatomic site distribution of gliomas in a coronal projection of the brain (facing the front). The colors represent the number of gliomas in each 1 × 1–cm square, with smoothing based on adjacent squares. The inset shows the section plane.
Fig. 3
Fig. 3
The anatomic site distribution of gliomas in a sagittal projection of the brain from the left (A) and from the right (B). The colors represent the number of gliomas in each 1 × 1–cm square, with smoothing based on adjacent squares. The inset shows the section plane.
See this image and copyright information in PMC

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