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. 2007 Jun;450(6):653-7.
doi: 10.1007/s00428-007-0430-7. Epub 2007 May 24.

Bone formation in cardiac valves: a histopathological study of 128 cases

Ivo Steiner  1 , Petra Kasparová, Ales Kohout, Jan Dominik
Affiliations

Bone formation in cardiac valves: a histopathological study of 128 cases

Ivo Steiner et al. Virchows Arch. 2007 Jun.

Abstract

In a series of 1,177 patients with surgical valve resection, there were 128 (10.9%) patients with the histological finding of bone and/or cartilage formation (bony metaplasia; heterotopic ossification) in the excised valve (119 aortic, 9 mitral). The incidence was higher in men (12.8%) than in women (8.5%). The bony metaplasia was always associated with valvular calcification. The metaplastic changes were encountered in all types of calcific aortic valve disease (senile, bicuspid valve, post-rheumatic). The marrow of the heterotopic lamellar bone was mostly composed of adipose tissue. Frequently, it showed chronic inflammation with polyclonal plasmocytic infiltration. Complete haematopoiesis was present only rarely.

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