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. 2007 Jun;120(6):552.e9-11.
doi: 10.1016/j.amjmed.2006.02.016.

High FVIII level is associated with idiopathic portal vein thrombosis in South India

Abraham Koshy  1 , Mary Jeyakumari
Affiliations

High FVIII level is associated with idiopathic portal vein thrombosis in South India

Abraham Koshy et al. Am J Med. 2007 Jun.

Abstract

Background: In the majority of the cases of portal vein thrombosis in India, the etiology cannot be determined. A high level of factor VIII (FVIII) is a risk factor for venous thromboembolism.

Methods: In this study from South India, FVIII was estimated in 32 patients with idiopathic portal vein thrombosis (PVT), 12 healthy controls and 12 disease controls with chronic liver disease.

Results: Eighty-four percent of the patients with portal vein thrombosis (27/32) vs 17% of healthy controls (2/12) had high factor VIII levels (P <.0001). FVIII levels were significantly different between the subset of PVT patients with normal liver function compared with healthy controls (P <.001) and also between the subset of PVT patients with abnormal liver function compared with disease controls (P <.05).

Conclusions: A high factor VIII level seems to contribute to the development of portal vein thrombosis in India.

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