Comment on

• ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

  Matsuoka S, Ballif BA, Smogorzewska A, McDonald ER 3rd, Hurov KE, Luo J, Bakalarski CE, Zhao Z, Solimini N, Lerenthal Y, Shiloh Y, Gygi SP, Elledge SJ. Matsuoka S, et al. Science. 2007 May 25;316(5828):1160-6. doi: 10.1126/science.1140321. Science. 2007. PMID: 17525332
• Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response.

  Wang B, Matsuoka S, Ballif BA, Zhang D, Smogorzewska A, Gygi SP, Elledge SJ. Wang B, et al. Science. 2007 May 25;316(5828):1194-8. doi: 10.1126/science.1139476. Science. 2007. PMID: 17525340 Free PMC article.
• RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites.

  Sobhian B, Shao G, Lilli DR, Culhane AC, Moreau LA, Xia B, Livingston DM, Greenberg RA. Sobhian B, et al. Science. 2007 May 25;316(5828):1198-202. doi: 10.1126/science.1139516. Science. 2007. PMID: 17525341 Free PMC article.
• Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage response.

  Kim H, Chen J, Yu X. Kim H, et al. Science. 2007 May 25;316(5828):1202-5. doi: 10.1126/science.1139621. Science. 2007. PMID: 17525342