Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2007 Jul;66(4):326-7.
doi: 10.1007/s00393-007-0178-0.

[A gene defect in the promoter of the endothelial NO synthase as a risk factor for rheumatoid arthritis]

[Article in German]
I Melchers  1 , M Cattaruzza
Affiliations
Review

[A gene defect in the promoter of the endothelial NO synthase as a risk factor for rheumatoid arthritis]

[Article in German]
I Melchers et al. Z Rheumatol. 2007 Jul.

Abstract

The risk to develop rheumatoid arthritis (RA) includes environmental as well as genetic factors. Moreover, RA, being an inflammatory disease, is itself considered to be a risk factor for coronary artery disease, as it - or its treatment - may lead to endothelial dysfunction. Likewise, a single nucleotide polymorphism in the promoter of the endothelial NO synthase ((-786)C/T) leads to endothelial dysfunction in (-786)CC homozygous individuals. This genetic defect occurs in significantly higher frequencies in patients with RA, and therefore must be regarded as a genetic risk factor for RA.

PubMed Disclaimer

Similar articles

See all similar articles

References

    1. Curr Opin Immunol. 2006 Dec;18(6):650-5 - PubMed
    1. Arthritis Rheum. 2006 Oct;54(10):3144-51 - PubMed
    1. J Biol Chem. 2003 Sep 26;278(39):37874-80 - PubMed
    1. Z Rheumatol. 2006 Oct;65(6):482, 484-6 - PubMed
    1. Circ Res. 2004 Oct 15;95(8):841-7 - PubMed

MeSH terms

Substances

LinkOut - more resources