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Review
. 2007 Jul;66(4):326-7.
doi: 10.1007/s00393-007-0178-0.

[A gene defect in the promoter of the endothelial NO synthase as a risk factor for rheumatoid arthritis]

[Article in German]
I Melchers  1 , M Cattaruzza
Affiliations
Review

[A gene defect in the promoter of the endothelial NO synthase as a risk factor for rheumatoid arthritis]

[Article in German]
I Melchers et al. Z Rheumatol. 2007 Jul.

Abstract

The risk to develop rheumatoid arthritis (RA) includes environmental as well as genetic factors. Moreover, RA, being an inflammatory disease, is itself considered to be a risk factor for coronary artery disease, as it - or its treatment - may lead to endothelial dysfunction. Likewise, a single nucleotide polymorphism in the promoter of the endothelial NO synthase ((-786)C/T) leads to endothelial dysfunction in (-786)CC homozygous individuals. This genetic defect occurs in significantly higher frequencies in patients with RA, and therefore must be regarded as a genetic risk factor for RA.

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References

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    1. Circ Res. 2004 Oct 15;95(8):841-7 - PubMed

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