Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2007 Aug;51(8):3001-3.
doi: 10.1128/AAC.00256-07. Epub 2007 May 25.

Changes in qnr prevalence and fluoroquinolone resistance in clinical isolates of Klebsiella pneumoniae and Enterobacter spp. collected from 1990 to 2005

Jacob Strahilevitz  1 , Dalia Engelstein, Amos Adler, Violeta Temper, Allon E Moses, Colin Block, Ari Robicsek
Affiliations

Changes in qnr prevalence and fluoroquinolone resistance in clinical isolates of Klebsiella pneumoniae and Enterobacter spp. collected from 1990 to 2005

Jacob Strahilevitz et al. Antimicrob Agents Chemother. 2007 Aug.

Abstract

Clinical isolates of Klebsiella pneumoniae and Enterobacter spp. collected from 1990 through 2005 at a tertiary care center were studied for qnr genes. Isolates bearing these genes emerged in the mid-1990s, coinciding with the time of a rapid increase in fluoroquinolone resistance. Sixty percent of these isolates were ciprofloxacin susceptible by CLSI breakpoints.

PubMed Disclaimer

Figures

FIG. 1.
FIG. 1.
Percentages of Enterobacter sp. isolates with the qnr gene and ciprofloxacin resistance. No qnr genes were found between 1990 and 1993.
FIG. 2.
FIG. 2.
Pulsed-field gel electrophoresis of 10 selected Enterobacter isolates after restriction with XbaI on 10 qnrB+ samples (Salmonella enterica serotype Braenderup provided the size marker). The dates of collection (month/year) and lane numbers are shown on the right, and molecular sizes in kilobases are at the bottom.
FIG. 3.
FIG. 3.
Percentages of K. pneumoniae isolates with the qnr gene and ciprofloxacin resistance. No qnr genes were found between 1991 and 1995.
See this image and copyright information in PMC

References

    1. Clinical and Laboratory Standards Institute. 2007. Performance standards for antimicrobial susceptibility testing; 15th informational supplement (M100-S17). Clinical and Laboratory Standards Institute, Wayne, PA.
    1. Gay, K., A. Robicsek, J. Strahilevitz, C. H. Park, G. Jacoby, T. J. Barrett, F. Medalla, T. M. Chiller, and D. C. Hooper. 2006. Plasmid-mediated quinolone resistance in non-Typhi serotypes of Salmonella enterica. Clin. Infect. Dis. 43:297-304. - PubMed
    1. Jacoby, G. A., and P. Han. 1996. Detection of extended-spectrum β-lactamases in clinical isolates of Klebsiella pneumoniae and Escherichia coli. J. Clin. Microbiol. 34:908-911. - PMC - PubMed
    1. Jacoby, G. A., K. E. Walsh, D. M. Mills, V. J. Walker, H. Oh, A. Robicsek, and D. C. Hooper. 2006. qnrB, another plasmid-mediated gene for quinolone resistance. Antimicrob. Agents Chemother. 50:1178-1182. - PMC - PubMed
    1. Martínez-Martínez, L., A. Pascual, and G. A. Jacoby. 1998. Quinolone resistance from a transferable plasmid. Lancet 351:797. - PubMed

MeSH terms