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Review
. 2007 Sep;64(18):2358-77.
doi: 10.1007/s00018-007-7120-0.

Role of heregulin in human cancer

M Breuleux  1
Affiliations
Review

Role of heregulin in human cancer

M Breuleux. Cell Mol Life Sci. 2007 Sep.

Abstract

Heregulin (HRG) is a soluble secreted growth factor, which, upon binding and activation of ErbB3 and ErbB4 transmembrane receptor tyrosine kinases, is involved in cell proliferation, invasion, survival and differentiation of normal and malignant tissues. The HRG gene family consists of four members: HRG-1, HRG-2, HRG-3 and HRG-4, of which a multitude of different isoforms are synthesized by alternative exon splicing, showing various tissue distribution and biological activities. Disruption of the physiological balance between HRG ligands and their ErbB receptors is implicated in the formation of a variety of human cancers. The general mechanisms involved in HRG-induced tumorigenesis is discussed.

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