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Review
. 2007 Aug 15;44(4):831-44.
doi: 10.1016/j.jpba.2007.04.022. Epub 2007 Apr 24.

Analytical methodologies for the determination of omeprazole: an overview

M Espinosa Bosch  1 , A J Ruiz Sánchez, F Sánchez Rojas, C Bosch Ojeda
Affiliations
Review

Analytical methodologies for the determination of omeprazole: an overview

M Espinosa Bosch et al. J Pharm Biomed Anal. .

Abstract

Omeprazole, a gastric acid pump inhibitor, dose-dependently controls gastric acid secretion; the drug has greater antisecretory activity than histamine H(2)-receptor antagonists. Omeprazole has been determined in formulations and biological fluids by a variety of methods such as spectrophotometry, high-performance liquid chromatography with ultraviolet detection and liquid chromatography coupled with tandem mass spectrometry. The overview includes the most relevant analytical methodologies used in its determination since the origin still today.

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