Review
doi: 10.1016/j.drudis.2007.04.009.
Epub 2007 May 7.
New developments in synthetic peroxidic drugs as artemisinin mimics
Affiliations
- PMID: 17532534
- DOI: 10.1016/j.drudis.2007.04.009
Item in Clipboard
Review
New developments in synthetic peroxidic drugs as artemisinin mimics
Drug Discov Today.
2007 Jun.
Abstract
The present review describes the current status of synthetic cyclic peroxides, trioxanes and trioxolanes that show significant promise as antimalarial drugs because of their artemisinin-like activity. The literature from 1996 onwards is critically surveyed to provide an update on how an age-old, persistent, debilitating and frequently deadly disease could be treated by new, affordable and effective medicines possessing the peroxide pharmacophore. The review is not exhaustive and does not cover recent progress on the lead structure artemisinin and its derivatives. Nevertheless, some mechanistic aspects gleaned from artemisinin that have relevance to synthetic peroxides are discussed.
Similar articles
-
Knowledge of the proposed chemical mechanism of action and cytochrome p450 metabolism of antimalarial trioxanes like artemisinin allows rational design of new antimalarial peroxides.Acc Chem Res. 2004 Jun;37(6):397-404. doi: 10.1021/ar020227u. Acc Chem Res. 2004. PMID: 15196049
-
Exploration of artemisinin derivatives and synthetic peroxides in antimalarial drug discovery research.Eur J Med Chem. 2021 Mar 5;213:113193. doi: 10.1016/j.ejmech.2021.113193. Epub 2021 Jan 18. Eur J Med Chem. 2021. PMID: 33508479 Review.
-
The therapeutic potential of semi-synthetic artemisinin and synthetic endoperoxide antimalarial agents.Expert Opin Investig Drugs. 2005 Sep;14(9):1117-28. doi: 10.1517/13543784.14.9.1117. Expert Opin Investig Drugs. 2005. PMID: 16144496 Review.
-
Considerations on the mechanism of action of artemisinin antimalarials: part 1--the 'carbon radical' and 'heme' hypotheses.Infect Disord Drug Targets. 2013 Aug;13(4):217-77. doi: 10.2174/1871526513666131129155708. Infect Disord Drug Targets. 2013. PMID: 24304352 Review.
-
Synthetic peroxides as potent antimalarials. News and views.Curr Top Med Chem. 2012;12(5):373-99. doi: 10.2174/156802612799362940. Curr Top Med Chem. 2012. PMID: 22242847 Review.
Cited by
-
Peroxides with Anthelmintic, Antiprotozoal, Fungicidal and Antiviral Bioactivity: Properties, Synthesis and Reactions.Molecules. 2017 Nov 2;22(11):1881. doi: 10.3390/molecules22111881. Molecules. 2017. PMID: 29099089 Free PMC article. Review.
-
The molecular mechanism of action of artemisinin--the debate continues.Molecules. 2010 Mar 12;15(3):1705-21. doi: 10.3390/molecules15031705. Molecules. 2010. PMID: 20336009 Free PMC article. Review.
-
Monoclonal Antibodies That Recognize the Alkylation Signature of Antimalarial Ozonides OZ277 (Arterolane) and OZ439 (Artefenomel).ACS Infect Dis. 2016 Jan 8;2(1):54-61. doi: 10.1021/acsinfecdis.5b00090. Epub 2015 Sep 28. ACS Infect Dis. 2016. PMID: 26819968 Free PMC article.
-
Cu(II)-catalyzed aerobic hydroperoxidation of Meldrum's acid derivatives and application in intramolecular oxidation: a conceptual blueprint for O2/H2 dihydroxylation.Org Lett. 2012 Dec 7;14(23):5932-5. doi: 10.1021/ol302848m. Epub 2012 Nov 19. Org Lett. 2012. PMID: 23163733 Free PMC article.
-
Oral activity of the antimalarial endoperoxide 6-(1,2,6,7-tetraoxaspiro[7.11]nonadec-4-yl)hexan-1-ol (N-251) against Leishmania donovani complex.PLoS Negl Trop Dis. 2019 Mar 25;13(3):e0007235. doi: 10.1371/journal.pntd.0007235. eCollection 2019 Mar. PLoS Negl Trop Dis. 2019. PMID: 30908481 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
