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. 2007 Jun;119(6):e1371-83.
doi: 10.1542/peds.2006-1232. Epub 2007 May 28.

Adherence to antiretroviral therapy for pediatric HIV infection: a qualitative systematic review with recommendations for research and clinical management

Jane M Simoni  1 , Arianna Montgomery, Erin Martin, Michelle New, Penelope A Demas, Sohail Rana
Affiliations

Adherence to antiretroviral therapy for pediatric HIV infection: a qualitative systematic review with recommendations for research and clinical management

Jane M Simoni et al. Pediatrics. 2007 Jun.

Abstract

Although nonadherence to prescribed therapies is widespread, it is particularly problematic with highly active antiretroviral therapy for HIV infection. This review of >50 studies in the area of pediatric HIV infection revealed varying methods for assessing antiretroviral adherence with a wide range of estimates of adherence. Correlates of adherence could be grouped as those relating to the medication, the patient, and the caregiver/family, with many conflicting findings and a lack of theory guiding the research. Only 8 studies, mainly small feasibility or pilot investigations, evaluated highly active antiretroviral therapy adherence interventions in pediatric populations. We conclude with specific recommendations for assessment and clinical management of adherence and discuss directions for future research in this area.

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References

    1. Haynes RB. Compliance in Health Care. Baltimore, MD: Johns Hopkins University; 1979.
    1. Besch CL. Compliance in clinical trials. AIDS. 1995;9:1–10. - PubMed
    1. Haynes RB, McKibbon KA, Kanani R. Systematic review of randomised trials of interventions to assist patients to follow prescriptions for medications [published correction appears in Lancet 1997;349:1180] Lancet. 1996;348:383–386. - PubMed
    1. Cramer JA, Mattson RH, Prevey ML, Scheyer RD, Ouellette VL. How often is medication taken as prescribed? A novel assessment technique [published correction appears in JAMA 1989; 262:1472] JAMA. 1989;261:3273–3277. - PubMed
    1. De Geest S, Borgermans L, Gemoets H, et al. Incidence, determinants, and consequences of subclinical noncompliance with immunosuppressive therapy in renal transplant recipients. Transplantation. 1995;59:340–347. - PubMed

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