Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2007 Dec;133(12):951-5.
doi: 10.1007/s00432-007-0238-5. Epub 2007 May 30.

Thy-1 as a potential novel diagnostic marker for gastrointestinal stromal tumors

Despoina Oikonomou  1 , Kambiz Hassan, Jussuf T Kaifi, Henning C Fiegel, Paulus G Schurr, Uta Reichelt, Kuniaki Aridome, Emre F Yekebas, Oliver Mann, Dietrich Kluth, Tim Strate, Jakob R Izbicki
Affiliations

Thy-1 as a potential novel diagnostic marker for gastrointestinal stromal tumors

Despoina Oikonomou et al. J Cancer Res Clin Oncol. 2007 Dec.

Abstract

Purpose: Only few immunohistochemical markers besides c-kit exist for gastrointestinal stromal tumors (GISTs). Thy-1, a cell-surface glycoprotein, is a marker for several types of stem cells and particularly for neuronal precursor cells. The aim of this study was to determine Thy-1 expression in GISTs.

Materials and methods: Fifty-seven surgically resected and paraffin-embedded GIST samples were analyzed by immunohistochemistry with peroxidase method for Thy-1 molecule.

Results: Thy-1 was detected in the majority of 57 GIST samples (54 out of 57 patients, 95%). All samples were c-kit positive and 90% were CD34 positive. All three Thy-1 negative samples were CD34 positive, had a low proliferative index (Ki-67 <or= 10%) and were located in the upper gastrointestinal tract (one in esophagus and two in the stomach). As a tendency, Thy-1 negative patients had a better prognosis, although not reaching level of significance due to low numbers.

Conclusions: Thy-1 is expressed in the majority of GISTs, suggesting a novel, additional standard marker for identifying GIST. Future studies should focus on the role of Thy-1 in the pathogenesis of GIST and subsequently on its potential to act as a molecular target for adjuvant therapy with new molecular antitumor agents.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Thy-1 positive GIST. Immunohistochemical staining was performed by the peroxidase method using monoclonal antibody against Thy-1. a, b Represent a Thy-1 positive gastric GIST (magnification ×100 and ×200, respectively)
See this image and copyright information in PMC

References

    1. Barnstable CJ, Drager UC (1984) Thy-1 antigen: a ganglion cell specific marker in rodent retina. Neuroscience 11:847–855 - PubMed
    1. Baselga J, Perez EA, Pienkowski T, Bell R (2006) Adjuvant trastuzumab: a milestone in the treatment of HER-2-positive early breast cancer. Oncologist 11(suppl 1):4–12 - PubMed
    1. Bernstein ID, Tam MR, Nowinski RC (1980) Mouse leukemia: therapy with monoclonal antibodies against a thymus differentiation antigen. Science 207:68–71 - PubMed
    1. Blay JY, Bonvalot S, Casali P, Choi H, Debiec-Richter M, Dei Tos AP, Emile JF, Gronchi A, Hogendoorn PC, Joensuu H, Le Cesne A, McClure J, Maurel J, Nupponen N, Ray-Coquard I, Reichardt P, Sciot R, Stroobants S, Van Glabbeke M, van Oosterom A, Demetri GD (2005) Consensus meeting for the management of gastrointestinal stromal tumors. Report of the GIST Consensus Conference of 20–21 March 2004, under the auspices of ESMO. Ann Oncol 16:566–578 - PubMed
    1. Buccisano F, Rossi FM, Venditti A, Del PG, Cox MC, Abbruzzese E, Rupolo M, Berretta M, Degan M, Russo S, Tamburini A, Maurillo L, Del Principe MI, Postorino M, Amadori S, Gattei V (2004) CD90/Thy-1 is preferentially expressed on blast cells of high risk acute myeloid leukaemias. Br J Haematol 125:203–212 - PubMed

Publication types