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. 2007 Oct;304(1-2):243-8.
doi: 10.1007/s11010-007-9506-6. Epub 2007 May 30.

CTRP3/cartducin promotes proliferation and migration of endothelial cells

Hironori Akiyama  1 , Souhei Furukawa, Satoshi Wakisaka, Takashi Maeda
Affiliations

CTRP3/cartducin promotes proliferation and migration of endothelial cells

Hironori Akiyama et al. Mol Cell Biochem. 2007 Oct.

Abstract

CTRP3/cartducin, a novel secretory protein, is a member of the C1q and tumor necrosis factor (TNF)-related protein (CTRP) superfamily. CTRP3/cartducin gene is transiently up-regulated in a balloon-injured rat carotid artery tissue. In this study, we report a new function of CTRP3/cartducin as a regulator of angiogenic processes. CTRP3/cartducin promoted proliferation and migration of mouse endothelial MSS31 cells in a dose-dependent manner. Further, stimulation of MSS31 by CTRP3/cartducin led to activation of extracellular signal-regulated kinase 1/2 (ERK1/2) and p38 mitogen-activated protein kinase (MAPK). MAPK/ERK kinase 1/2 (MEK1/2) inhibitor, U0126, and p38 MAPK inhibitor, SB203580, blocked the CTRP3/cartducin-induced cell proliferation, and migration was blocked by U0126, but not the SB203580. Taken together, these results suggest that CTRP3/cartducin may be involved as a novel angiogenic factor in the formation of neointima following angioplasty.

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