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Comment
. 2007 Jun 5;104(23):9551-2.
doi: 10.1073/pnas.0703910104. Epub 2007 May 29.

A simplified recipe for prions

Kil Sun Lee  1 , Byron Caughey
Affiliations
Comment

A simplified recipe for prions

Kil Sun Lee et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Models of prion multiplication by PMCA and endocytosis-mediated shearing. (A) PMCA flow chart. (B) Seeded polymerization model for PrPSc formation. (C) Hypothetical model for shearing of PrPSc aggregates in a cell by endocytosis, a process in which cellular machinery drives the inward budding of membrane-bound vesicles. These vesicles (endosomes) can then recycle their contents (e.g., fragmented PrPSc seeds) back to the cell surface or transport them to distal subcellular locations for potential transfer to other cells.
See this image and copyright information in PMC

Comment on

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