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Comment
. 2007 Jun;129(6):457-9.
doi: 10.1085/jgp.200709814.

And yet it moves: conformational States of the Ca2+ channel pore

Riccardo Olcese  1
Affiliations
Comment

And yet it moves: conformational States of the Ca2+ channel pore

Riccardo Olcese. J Gen Physiol. 2007 Jun.
No abstract available

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Figures

Figure 1.
Figure 1.
Voltage- and Ca2+-dependent gating in the Ca2+ channel pore. In addition to the opening of the gate at the intracellular mouth, activation also involves voltage-dependent preopening pore transitions that lower the affinity of an external Ca2+ binding site at the pore entrance. Inactivation abolishes Ca2+ conduction by increasing Ca2+ affinity of this site. Ca2+ binding to intracellularly located CAM stabilizes the inactivated site with Ca2+ bound to the pore, accelerating inactivation.
See this image and copyright information in PMC

Comment on

References

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