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. 2007 May 29;68(22):1944-6.
doi: 10.1212/01.wnl.0000263188.77797.99.

A controlled study of reverse transcriptase in serum and CSF of HIV-negative patients with ALS

D J L MacGowan  1 , S N Scelsa, T E Imperato, K-N Liu, P Baron, B Polsky
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A controlled study of reverse transcriptase in serum and CSF of HIV-negative patients with ALS

D J L MacGowan et al. Neurology. .

Abstract

Reverse transcriptase has been detected in the serum of HIV-negative patients with amyotrophic lateral sclerosis (ALS). An ALS-like disorder in HIV-positive patients can remit with antiretroviral therapy. Using the product enhanced assay technique, we measured reverse transcriptase activity in the serum and CSF of 23 HIV-negative patients with ALS and 21 neurologic disease controls. Results for CSF were not significant, whereas reverse transcriptase was detected in 56% of ALS sera vs 19% of controls.

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