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. 2007 Aug;45(8):2720-2.
doi: 10.1128/JCM.00162-07. Epub 2007 May 30.

Host genetic resistance to symptomatic norovirus (GGII.4) infections in Denmark

Elin Kindberg  1 , Britt Akerlind, Christina Johnsen, Jenny Dahl Knudsen, Ole Heltberg, Göran Larson, Blenda Böttiger, Lennart Svensson
Affiliations

Host genetic resistance to symptomatic norovirus (GGII.4) infections in Denmark

Elin Kindberg et al. J Clin Microbiol. 2007 Aug.

Abstract

A total of 61 individuals involved in five norovirus outbreaks in Denmark were genotyped at nucleotides 428 and 571 of the FUT2 gene, determining secretor status, i.e., the presence of ABH antigens in secretions and on mucosa. A strong correlation (P = 0.003) was found between the secretor phenotype and symptomatic disease, extending previous knowledge and confirming that nonsense mutations in the FUT2 gene provide protection against symptomatic norovirus (GGII.4) infections.

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