Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2007 May 30;27(22):5845-6; discussion 5845.
doi: 10.1523/JNEUROSCI.1838-07.2007.

A critical time for new neurons in the adult hippocampus

Benedetta Leuner  1 , Erica R Glasper, Christian Mirescu
Affiliations
Review

A critical time for new neurons in the adult hippocampus

Benedetta Leuner et al. J Neurosci. .
No abstract available

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Simplified schematic diagram of the results presented by Tashiro et al. (2007). Exposure to environmental enrichment during a critical period (1–3 weeks after BrdU administration; bottom) increased the survival of new neurons in the dentate gyrus (BrdU+/NeuN+). In contrast, new neuron survival was not enhanced in mice exposed to an enriched environment after the critical period (top). The authors also demonstrated that reexposure to the same experience of environmental enrichment at a later time enhanced neuronal activation (BrdU+/NeuN+/Zif268+; bottom). Increased neuronal activation did not occur when mice were only given the initial exposure or were reexposed to a different experience of water maze training.
See this image and copyright information in PMC

Comment on

References

    1. Ge S, Goh EL, Sailor KA, Kitabatake Y, Ming GL, Song H. GABA regulates synaptic integration of newly generated neurons in the adult brain. Nature. 2006;439:589–593. - PMC - PubMed
    1. Hastings ND, Gould E. Rapid extension of axons into the CA3 region by adult-generated granule cells. J Comp Neurol. 1999;413:146–154. - PubMed
    1. Kee N, Teixeira CM, Wang AH, Frankland PW. Preferential incorporation of adult-generated granule cells into spatial memory networks in the dentate gyrus. Nat Neurosci. 2007;10:355–362. - PubMed
    1. Kempermann G, Kuhn HG, Gage FH. More hippocampal neurons in adult mice living in an enriched environment. Nature. 1997;386:493–495. - PubMed
    1. Leuner B, Mendolia-Loffredo S, Kozorovitskiy Y, Samburg D, Gould E, Shors TJ. Learning enhances the survival of new neurons beyond the time when the hippocampus is required for memory. J Neurosci. 2004;24:7477–7481. - PMC - PubMed

LinkOut - more resources