Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2007 Jul 1;196(1):10-4.
doi: 10.1086/518511. Epub 2007 May 24.

Late postnatal transmission of HIV-1 and associated factors

Taha E Taha  1 , Donald R Hoover, Newton I Kumwenda, Susan A Fiscus, George Kafulafula, Chiwawa Nkhoma, Shu Chen, Estelle Piwowar, Robin L Broadhead, J Brooks Jackson, Paolo G Miotti
Affiliations
Randomized Controlled Trial

Late postnatal transmission of HIV-1 and associated factors

Taha E Taha et al. J Infect Dis. .

Abstract

Background: The present study was undertaken to determine the risk and timing of late postnatal transmission (LPT) of human immunodeficiency virus type 1 (HIV-1).

Methods: Breast-fed infants previously enrolled in 2 trials of antiretroviral prophylaxis were monitored in Malawi. Kaplan-Meier and proportional hazard models assessed cumulative incidence and association of factors with LPT.

Results: Overall, 98 infants were HIV infected, and 1158 were uninfected. The cumulative risk of LPT at age 24 months was 9.68% (95% confidence interval, 7.80%-11.56%). The interval hazards at 1.5-6, 6-12, 12-18, and 18-24 months were 1.22%, 4.05%, 3.48%, and 1.27%, respectively.

Conclusions: The risk of LPT beyond 6 months is substantial. Weaning at 6 months could prevent >85% of LPT.

PubMed Disclaimer

Comment in

Publication types