T cells in the liver: there is life beyond the graveyard
- PMID: 17538934
- DOI: 10.1002/hep.21786
T cells in the liver: there is life beyond the graveyard
Abstract
Influenza A virus infection of C57BL/6 mice is a well-characterized model for studying CD8+ T cell-mediated immunity. Analysis of primary and secondary responses showed that the liver is highly enriched for CD8+ T cells specific for the immunodominant H2D(b)NP(366-374) (D(b)NP(366)) epitope. Functional analysis established that these liver-derived virus-specific CD8+ T cells are fully competent cytotoxic effectors and IFN-gamma secretors. In addition, flow cytometric analysis of early apoptotic cells showed that these influenza-specific CD8+ T cells from liver are as viable as those in the spleen, bronchoalveolar lavage, mediastinal lymph nodes, or lung. Moreover, cytokine profiles of the influenza-specific CD8+ T cells recovered from different sites were consistent with the bronchoalveolar lavage, rather than liver population, being the most susceptible to activation-induced cell death. Importantly, adoptively transferred influenza virus-specific CD8+ T cells from the liver survived and were readily recalled after virus challenge. Together, these results show clearly that the liver is not a "graveyard" for influenza virus-specific CD8+ T cells.
Comment on
-
Virus-specific CD8+ T cells in the liver: armed and ready to kill.J Immunol. 2007 Mar 1;178(5):2737-45. doi: 10.4049/jimmunol.178.5.2737. J Immunol. 2007. PMID: 17312116
Publication types
LinkOut - more resources
Full Text Sources
Research Materials
Miscellaneous