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Comment
. 2007 Jun 1;129(5):853-5.
doi: 10.1016/j.cell.2007.05.023.

Chronic lymphocytic leukemia: keeping cell death at bay

Klaus-Michael Debatin  1
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Free article
Comment

Chronic lymphocytic leukemia: keeping cell death at bay

Klaus-Michael Debatin. Cell. .
Free article

Abstract

Chronic lymphocytic leukemia (CLL) is a common adult leukemia caused by abnormal accumulation of B cells. Raval et al. (2007) now implicate dowregulation of the expression of the kinase DAPK1 both genetically and epigenetically in familial and sporadic CLL.

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  • Downregulation of death-associated protein kinase 1 (DAPK1) in chronic lymphocytic leukemia.
    Raval A, Tanner SM, Byrd JC, Angerman EB, Perko JD, Chen SS, Hackanson B, Grever MR, Lucas DM, Matkovic JJ, Lin TS, Kipps TJ, Murray F, Weisenburger D, Sanger W, Lynch J, Watson P, Jansen M, Yoshinaga Y, Rosenquist R, de Jong PJ, Coggill P, Beck S, Lynch H, de la Chapelle A, Plass C. Raval A, et al. Cell. 2007 Jun 1;129(5):879-90. doi: 10.1016/j.cell.2007.03.043. Cell. 2007. PMID: 17540169 Free PMC article.

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