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Review
. 2007 Jun;28(6):1317-30.
doi: 10.1016/j.peptides.2007.04.023. Epub 2007 May 6.

Adipokines and the blood-brain barrier

Weihong Pan  1 , Abba J Kastin
Affiliations
Review

Adipokines and the blood-brain barrier

Weihong Pan et al. Peptides. 2007 Jun.

Abstract

Just as the blood-brain barrier (BBB) is not a static barrier, the adipocytes are not inert storage depots. Adipokines are peptides or polypeptides produced by white adipose tissue; they play important roles in normal physiology as well as in the metabolic syndrome. Adipokines secreted into the circulation can interact with the BBB and exert potent CNS effects. The specific transport systems for two important adipokines, leptin and tumor necrosis factor alpha, have been characterized during the past decade. By contrast, transforming growth factor beta-1 and adiponectin do not show specific permeation across the BBB, but modulate endothelial functions. Still others, like interleukin-6, may reach the brain but are rapidly degraded. This review summarizes current knowledge and recent findings of the rapidly growing family of adipokines and their interactions with the BBB.

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Figures

Fig.1
Fig.1
Gel distribution in pI-MW plot.
Fig. 2
Fig. 2
Restricted CNS permeation of adiponectin
See this image and copyright information in PMC

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