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. 2007 Mar-Apr;25(2):225-30.

Cytokine patterns in fibromyalgia and their correlation with clinical manifestations

L Bazzichi  1 , A Rossi, G Massimetti, G Giannaccini, T Giuliano, F De Feo, A Ciapparelli, L Dell'Osso, S Bombardieri
Affiliations
  • PMID: 17543146

Cytokine patterns in fibromyalgia and their correlation with clinical manifestations

L Bazzichi et al. Clin Exp Rheumatol. 2007 Mar-Apr.

Abstract

Objective: To examine the possible role of the soluble factor in fibromyalgia (FM) by studying the correlation of cytokine levels with the patients' clinical and psychiatric profile.

Methods: Eighty FM patients underwent clinical and psychiatric evaluations, and plasma levels of cytokines (IL-1, IL-6, IL-8, IL-10, TNF-alpha), aspecific markers of inflammation, rheumatoid factor (RF), anti-extractable nuclear antigen (ENA) antibodies, and anti-nuclear factor (FAN) were measured.

Results: Higher levels of IL-10, IL-8 and TNF-alpha were found in FM patients than in controls. Significant correlations between the biochemical parameters and clinical data were found.

Conclusion: The higher levels of cytokines found in FM patients suggest the presence of an inflammatory response system (IRS) and highlight a parallel between the clinical symptoms and biochemical data. They support the hypothesis that cytokines may play a role in the clinical features of fibromyalgia. In addition, the similar cytokine patterns found in FM patients with different psychiatric profiles suggests that IRS impairment may play a specific role in the disease.

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