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Review
. 2007 Oct;33(6):499-505.
doi: 10.1016/j.ctrv.2007.04.007. Epub 2007 Jun 4.

Epstein-Barr virus-targeted immunotherapy for nasopharyngeal carcinoma

Amine Masmoudi  1 , Nabil Toumi, Afef Khanfir, Lamia Kallel-Slimi, Jamel Daoud, Hela Karray, Mounir Frikha
Affiliations
Review

Epstein-Barr virus-targeted immunotherapy for nasopharyngeal carcinoma

Amine Masmoudi et al. Cancer Treat Rev. 2007 Oct.

Abstract

Epstein-Barr virus (EBV) is constantly present in undifferentiated and poorly-differentiated nasopharyngeal cancer. Thus, tumour-associated viral antigens are potential targets for immunotherapy. Recently, both preclinical and early clinical studies have shown that various strategies can enhance EBV-specific immunity. Moreover, significant anti-tumour effect has been observed, and was generally correlated with biological response. The present review discusses the rational for EBV-targeted immunotherapy and summarises the latest developments in this area.

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