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Case Reports
. 2007 Apr-Jun;21(2):164-6.
doi: 10.1097/WAD.0b013e318047df5d.

Memantine for behavioral disturbances in frontotemporal dementia: a case series

Margaret M Swanberg  1
Affiliations
Case Reports

Memantine for behavioral disturbances in frontotemporal dementia: a case series

Margaret M Swanberg. Alzheimer Dis Assoc Disord. 2007 Apr-Jun.

Abstract

Background: Frontotemporal dementia (FTD) is one of the more common presenile dementias. Unlike Alzheimer disease, there are no approved medications to treat this debilitating condition.

Objective: To report the response of memantine on the behavioral manifestations of FTD.

Design: Case series of 3 patients diagnosed with FTD and treated with memantine.

Results: All 3 patients showed an improvement in total Neuropsychiatric Inventory score with specific improvements in the subscale scores of apathy, agitation, and anxiety. Memantine was well tolerated in all patients.

Conclusions: This small case series supports the notion that memantine may have a beneficial effect on the neuropsychiatric symptoms of FTD and should be further studied in a prospective clinical trial.

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