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. 2007 Jul 30;22(10):1481-1484.
doi: 10.1002/mds.21399.

Lysosomal hydrolases in cerebrospinal fluid from subjects with Parkinson's disease

Chiara Balducci  1 , Laura Pierguidi  2   3 , Emanuele Persichetti  1 , Lucilla Parnetti  2 , Michele Sbaragli  1 , Carmelo Tassi  4 , Aldo Orlacchio  4 , Paolo Calabresi  2   3 , Tommaso Beccari  1 , Aroldo Rossi  2
Affiliations

Lysosomal hydrolases in cerebrospinal fluid from subjects with Parkinson's disease

Chiara Balducci et al. Mov Disord. .

Abstract

Recent studies have shown a genetic association between glucocerebrosidase deficiencies and Parkinson's disease (PD). To further explore this issue the activity of beta-glucocerebrosidase and the activities of other lysosomal enzymes, alpha-mannosidase, beta-mannosidase, beta-hexosaminidase, and beta-galactosidase have been evaluated in the cerebrospinal fluid (CSF) of PD patients. The activities of alpha-mannosidase, beta-mannosidase, beta-glucocerebrosidase, and beta-hexosaminidase were substantially decreased in the CSF of PD patients, while levels of beta-galactosidase were essentially identical to controls. This study indicates that in PD several lysosomal hydrolases have decreased activities, further supporting a possible link between pathophysiological mechanisms underlying PD and lysosomal hydrolases.

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References

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