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. 2007 Jul 6;72(14):5411-3.
doi: 10.1021/jo070492z. Epub 2007 Jun 6.

Highly enantioselective conjugate addition of thiols using mild scandium triflate catalysis

Aki M M Abe  1 , Sami J K Sauerland, Ari M P Koskinen
Affiliations

Highly enantioselective conjugate addition of thiols using mild scandium triflate catalysis

Aki M M Abe et al. J Org Chem. .

Abstract

A Sc complex of (4S,5S)-diphenyl PYBOX 1 was found to serve as a catalyst for the asymmetric conjugate addition reactions between various thiols and 3-crotonoyl-2-oxazolidinone, affording the corresponding adducts in good yields and high enantioselectivies (up to 92% ee). A new improved method for making (4S,5S)-diphenyl PYBOX is presented.

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