Comment
doi: 10.1016/j.cmet.2007.05.010.
FGF21: a missing link in the biology of fasting
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- PMID: 17550773
- DOI: 10.1016/j.cmet.2007.05.010
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Comment
FGF21: a missing link in the biology of fasting
Cell Metab.
2007 Jun.
Free article
Abstract
A sufficient energy supply is essential for life; consequently, multiple mechanisms have evolved to ensure both energy availability and conservation during fasting and starvation. Two reports in this issue of Cell Metabolism (Badman et al., 2007; Inagaki et al., 2007) demonstrate that FGF21, a circulating protein produced in the liver in response to the PPARalpha transcription factor, is a "missing link" in the biology of fasting, inducing adipose tissue lipolysis, liver ketogenesis, and metabolic adaptation to the fasting state.
Comment on
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Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21.Cell Metab. 2007 Jun;5(6):415-25. doi: 10.1016/j.cmet.2007.05.003. Cell Metab. 2007. PMID: 17550777
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Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states.Cell Metab. 2007 Jun;5(6):426-37. doi: 10.1016/j.cmet.2007.05.002. Cell Metab. 2007. PMID: 17550778
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