Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2007 Jun;44(6):e80.
doi: 10.1136/jmg.2007.048876.

Mitochondrial DNA haplogroups and type 2 diabetes: a study of 897 cases and 1010 controls

P F Chinnery  1 , C Mowbray, S K Patel, J L Elson, M Sampson, G A Hitman, M I McCarthy, A T Hattersley, M Walker
Affiliations

Mitochondrial DNA haplogroups and type 2 diabetes: a study of 897 cases and 1010 controls

P F Chinnery et al. J Med Genet. 2007 Jun.

Abstract

Mitochondria play a central role in the secretion of insulin by pancreatic beta-cells, and pathogenic mutations of mitochondrial DNA (mtDNA) can cause diabetes. The aetiology of type 2 diabetes has a strong genetic component, raising the possibility that genetic variants of mtDNA alter the risk of developing the disorder. Recent studies have produced conflicting results. By studying 897 UK cases of type 2 diabetes and 1010 population-matched controls, it is shown that European mtDNA haplogroups are unlikely to play a major role in the risk of developing the disorder.

PubMed Disclaimer

Conflict of interest statement

Competing interests: None declared.

References

    1. Moreno‐Loshuertos R, Acin‐Perez R, Fernandez‐Silva P, Movilla N, Perez‐Martos A, de Cordoba S R, Gallardo M E, Enriquez J A. Differences in reactive oxygen species production explain the phenotypes associated with common mouse mitochondrial DNA variants. Nat Genet 2006381261–1268. - PubMed
    1. Poulton J, Luan J, Macaulay V, Hennings S, Mitchell J, Wareham N J. Type 2 diabetes is associated with a common mitochondrial variant: evidence from a population‐based case–control study. Hum Mol Genet 2002111581–1583. - PubMed
    1. Chinnery P F, Elliott H R, Patel S, Lambert C, Keers S M, Durham S E, McCarthy M I, Hitman G A, Hattersley A T, Walker M. Role of the mitochondrial DNA 16184–16193 poly‐C tract in type 2 diabetes. Lancet 20053661650–1651. - PubMed
    1. Saxena R, de Bakker P I, Singer K, Mootha V, Burtt N, Hirschhorn J N, Gaudet D, Isomaa B, Daly M J, Groop L, Ardlie K G, Altshuler D. Comprehensive association testing of common mitochondrial DNA variation in metabolic disease. Am J Hum Genet 20067954–61. - PMC - PubMed
    1. Crispim D, Canani L H, Gross J L, Tschiedel B, Souto K E, Roisenberg I. The European‐specific mitochondrial cluster J/T could confer an increased risk of insulin‐resistance and type 2 diabetes: an analysis of the m.4216T>C and m.4917A>G variants. Ann Hum Genet 200670(Pt 4)488–495. - PubMed

Publication types

Substances