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. 2007 May 14;13(18):2622-5.
doi: 10.3748/wjg.v13.i18.2622.

Expression level of beta-catenin is associated with prognosis of esophageal carcinoma

Lv Ji  1 , Xiu-Feng Cao, He-Ming Wang, Yi-Sheng Li, Bin Zhu, Jian Xiao, Dan Wang
Affiliations

Expression level of beta-catenin is associated with prognosis of esophageal carcinoma

Lv Ji et al. World J Gastroenterol. .

Abstract

Aim: To examine the association of beta-catenin with the clinicopathologic features and prognosis of esophageal squamous cell carcinoma (ESCC).

Methods: Beta-catenin mRNA expression level in 40 ESCC patients (28 males and 12 females, age range 38-82 years, median 60 years) was analyzed by real-time PCR. Beta-catenin mRNA expression levels in tumor cells were categorized as weaker (level 1) or equal to or stronger (level 2) than those in endothelial cells. We examined the correlation between the beta-catenin expression and the clinicopathological factors and prognosis of ESCC patients.

Results: Level 2 beta-catenin expression was found in 29 patients. ESCC with level 2 expression had a higher rate of lymphnode metastasis (0.0776 +/- 0.0369 vs 0.3413 +/- 0.1803, P < 0.001) and deeper tumor invasion (0.0751 +/- 0.0356 vs 0.3667 +/- 0.1928, P < 0.001), and a poorer survival rate (P = 0.0024) than ESCC with level 1 expression.

Conclusion: Beta-catenin expression in ESCC is of great importance.

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Figures

Figure 1
Figure 1
Solution curve of beta-catenin gone PCR products (A and standard curve of beta-catenin gone PCR products (B).
Figure 2
Figure 2
A: ESCC patients at stages III- IV(A) showing higher mRNA expression level of beta-catenin than ESCC patients at stages I-II(B). Y: observed lymph node metastasis, N: no lymph node metastasis. ESCC patients with lymph node metastasis had higher mRNA expression level of beta-catenin than ESCC patients with no lymph node metastasis.
Figure 3
Figure 3
At the advanced stage (pT2-pT4), a significant difference in survival between patients at advanced stage with level 1 and 2 expression.
See this image and copyright information in PMC

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