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Case Reports
. 2007 Mar;13(3):472-5.
doi: 10.3201/eid1303.061141.

Mouse-to-human transmission of variant lymphocytic choriomeningitis virus

Sébastien Emonet  1 , Karine Retornaz, Jean-Paul Gonzalez, Xavier de Lamballerie, Rémi N Charrel
Affiliations
Case Reports

Mouse-to-human transmission of variant lymphocytic choriomeningitis virus

Sébastien Emonet et al. Emerg Infect Dis. 2007 Mar.

Abstract

A case of lymphocytic choriomeningitis virus (LCMV) infection led to investigation of the reservoir. LCMV was detected in mice trapped at the patient's home, and 12 isolates were recovered. Genetic analysis showed that human and mouse LCMVs were identical and that this LCMV strain was highly divergent from previously characterized LCMV.

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Figures

Figure
Figure
Phylogenetic tree based on 400-nt sequences amplified by PCR system 1 in the nucleoprotein gene. Lymphocytic choriomeningitis virus (LCMV) sequences characterized in this study were compared with selected homologous LCMV sequences available in the GenBank database. Sequence information corresponds to virus/nature of specimen/host/GenBank accession no. (optional), except for sequences retrieved from GenBank (virus strain/GenBank accession no.). Sequences determined in this study are in bold type. The 15 sequences determined from mouse material were almost identical and most closely related to LCMV sequence corresponding to the patient cerebrospinal fluid. These 16 sequences were grouped together and were clearly distinct from other LCMV strains included in the study (Armstrong, CH, MX, WE) and from Traub and Pasteur strains (data not shown).
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References

    1. Childs JE, Peters CJ. Ecology and epidemiology of arenaviruses and their hosts. In: Salvato MS, editor. The Arenaviridae. New York: Plenum Press;1993. p. 331–84.
    1. Barton LL, Hyndman NJBB. Lymphocytic choriomeningitis virus: reemerging central nervous system pathogen. Pediatrics. 2000;105:E35. 10.1542/peds.105.3.e35 - DOI - PubMed
    1. Barton LL. Lymphocytic choriomeningitis virus: a neglected central nervous system pathogen. Clin Infect Dis. 1996;22:197. - PubMed
    1. Barton LL, Peters CJ, Ksiazek TG. Lymphocytic choriomeningitis virus: an unrecognized teratogenic pathogen. Emerg Infect Dis. 1995;1:152–3. - PMC - PubMed
    1. Fischer SA, Graham MB, Kuehnert MJ, Kotton CN, Srinivasan A, Marty FM, et al. Transmission of lymphocytic choriomeningitis virus by organ transplantation. N Engl J Med. 2006;354:2235–49. 10.1056/NEJMoa053240 - DOI - PubMed

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