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. 2007 Apr;13(4):608-10.
doi: 10.3201/eid1304.061063.

Endpoints for lymphatic filariasis programs

Caroline A Grady  1 , Madsen Beau de Rochars, Abdel N Direny, Jean Nicolas Orelus, Joyanna Wendt, Jeanne Radday, Els Mathieu, Jacquelin M Roberts, Thomas G Streit, David G Addiss, Patrick J Lammie
Affiliations

Endpoints for lymphatic filariasis programs

Caroline A Grady et al. Emerg Infect Dis. 2007 Apr.

Abstract

In 2000, annual mass administration of diethlycarbamazine and albendazole began in Leogane Commune, Haiti, to interrupt transmission of lymphatic filariasis (LF). After 5 years of treatment, microfilaremia, antigenemia, and mosquito infection rates were significantly reduced, but LF transmission was not interrupted. These finding have implications for other LF elimination programs.

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Figures

Figure 1
Figure 1
Microfilaremia prevalence determined by screening thick blood films before and 6–9 months after annual mass drug administration in sentinel sites in Leogane Commune, Haiti. Blood samples (20 μL) were collected from 7–9 PM.
Figure 2
Figure 2
Prevalence of infection (microfilaremia, L1, L2, and L3) in dissected mosquitoes collected by using gravid traps in sentinel sites in Leogane Commune, Haiti. Data are aggregated on a monthly basis. Dashed lines represent annual mass drug administration intervention.
See this image and copyright information in PMC

References

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