Review
doi: 10.1016/j.neuron.2007.05.018.
Caspase-3 cleavage of GGA3 stabilizes BACE: implications for Alzheimer's disease
Affiliations
- PMID: 17553417
- DOI: 10.1016/j.neuron.2007.05.018
Item in Clipboard
Review
Caspase-3 cleavage of GGA3 stabilizes BACE: implications for Alzheimer's disease
Neuron.
.
Free article
Abstract
BACE initiates the production of beta-amyloid (Abeta), the likely cause of Alzheimer's disease (AD). In this issue of Neuron, Tesco et al. show that during apoptosis caspase-3 cleaves the adaptor protein GGA3, which is required for BACE lysosomal degradation, consequently stabilizing BACE and elevating Abeta generation.
Comment on
-
Depletion of GGA3 stabilizes BACE and enhances beta-secretase activity.Neuron. 2007 Jun 7;54(5):721-37. doi: 10.1016/j.neuron.2007.05.012. Neuron. 2007. PMID: 17553422 Free PMC article.
Similar articles
-
Decreased expression of GGA3 protein in Alzheimer's disease frontal cortex and increased co-distribution of BACE with the amyloid precursor protein.Neurobiol Dis. 2011 Jul;43(1):176-83. doi: 10.1016/j.nbd.2011.03.009. Epub 2011 Apr 3. Neurobiol Dis. 2011. PMID: 21440067
-
Oral administration of a potent and selective non-peptidic BACE-1 inhibitor decreases beta-cleavage of amyloid precursor protein and amyloid-beta production in vivo.J Neurochem. 2007 Feb;100(3):802-9. doi: 10.1111/j.1471-4159.2006.04260.x. J Neurochem. 2007. PMID: 17156133
-
Depletion of GGA3 stabilizes BACE and enhances beta-secretase activity.Neuron. 2007 Jun 7;54(5):721-37. doi: 10.1016/j.neuron.2007.05.012. Neuron. 2007. PMID: 17553422 Free PMC article.
-
Protein-protein interactions in the assembly and subcellular trafficking of the BACE (beta-site amyloid precursor protein-cleaving enzyme) complex of Alzheimer's disease.Biochem Soc Trans. 2007 Nov;35(Pt 5):974-9. doi: 10.1042/BST0350974. Biochem Soc Trans. 2007. PMID: 17956258 Review.
-
Expression and activity of beta-site amyloid precursor protein cleaving enzyme in Alzheimer's disease.Biochem Soc Trans. 2005 Nov;33(Pt 5):1096-100. doi: 10.1042/BST20051096. Biochem Soc Trans. 2005. PMID: 16246054 Review.
Cited by
-
Molecular mechanism of Acanthopanax senticosus in the treatment of Alzheimer's disease based on network pharmacology and molecular docking.Mol Divers. 2023 Dec;27(6):2849-2865. doi: 10.1007/s11030-022-10586-3. Epub 2022 Dec 28. Mol Divers. 2023. PMID: 36576665
-
High-Phytate Diets Increase Amyloid β Deposition and Apoptotic Neuronal Cell Death in a Rat Model.Nutrients. 2021 Dec 6;13(12):4370. doi: 10.3390/nu13124370. Nutrients. 2021. PMID: 34959925 Free PMC article.
-
Chronic administration of anti-stroke herbal medicine TongLuoJiuNao reduces amyloidogenic processing of amyloid precursor protein in a mouse model of Alzheimer's disease.PLoS One. 2013;8(3):e58181. doi: 10.1371/journal.pone.0058181. Epub 2013 Mar 5. PLoS One. 2013. PMID: 23472157 Free PMC article.
-
Generation and Characterization of the First Murine Model of Alzheimer's Disease with Mutated AβPP Inserted in a BALB/c Background (C.B6/J-APPswe).J Alzheimers Dis. 2023;93(4):1485-1508. doi: 10.3233/JAD-230195. J Alzheimers Dis. 2023. PMID: 37182890 Free PMC article.
-
Association of brain pathology with the progression of frailty in older adults.Neurology. 2013 May 28;80(22):2055-61. doi: 10.1212/WNL.0b013e318294b462. Epub 2013 May 1. Neurology. 2013. PMID: 23635961 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Research Materials
