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. 2007 Oct-Dec;21(5-6):405-7.
doi: 10.1016/j.mcp.2007.04.001. Epub 2007 Apr 21.

Detection of an unstable non-coding tandem repeat in the ZNF291 gene

Vallo Laura  1 , Bonifazi Emanuela, Angelini Corrado, Novelli Giuseppe, Botta Annalisa
Affiliations

Detection of an unstable non-coding tandem repeat in the ZNF291 gene

Vallo Laura et al. Mol Cell Probes. 2007 Oct-Dec.

Abstract

Repeat instability is an important form of mutation that is responsible for several neurological, neurodegenerative and neuromuscular disorders. In this study we identified an unstable [CCTG](n) repeat in the second intron of the ZNF291 gene, on chromosome 15q21-24. The repeat number is polymorphic in normal population and the ZNF291 transcript is expressed in different areas of human brain, skeletal muscle and heart. These findings suggest that ZNF291 gene should be taken in consideration as an attractive candidate for neuromuscular expansion related diseases mapping in this locus.

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