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. 2007 Jul;39(7):830-2.
doi: 10.1038/ng2061. Epub 2007 Jun 6.

Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility

Miles Parkes  1 , Jeffrey C Barrett, Natalie J Prescott, Mark Tremelling, Carl A Anderson, Sheila A Fisher, Roland G Roberts, Elaine R Nimmo, Fraser R Cummings, Dianne Soars, Hazel Drummond, Charlie W Lees, Saud A Khawaja, Richard Bagnall, Denis A Burke, Catherine E Todhunter, Tariq Ahmad, Clive M Onnie, Wendy McArdle, David Strachan, Graeme Bethel, Claire Bryan, Cathryn M Lewis, Panos Deloukas, Alastair Forbes, Jeremy Sanderson, Derek P Jewell, Jack Satsangi, John C Mansfield; Wellcome Trust Case Control Consortium; Lon Cardon, Christopher G Mathew
Affiliations

Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility

Miles Parkes et al. Nat Genet. 2007 Jul.

Abstract

A genome-wide association scan in individuals with Crohn's disease by the Wellcome Trust Case Control Consortium detected strong association at four novel loci. We tested 37 SNPs from these and other loci for association in an independent case-control sample. We obtained replication for the autophagy-inducing IRGM gene on chromosome 5q33.1 (replication P = 6.6 x 10(-4), combined P = 2.1 x 10(-10)) and for nine other loci, including NKX2-3, PTPN2 and gene deserts on chromosomes 1q and 5p13.

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Figures

Figure 1
Figure 1
Associated region at the gene IRGM. Strength of association of Affymetrix 500K SNPs in the region, with combined p-values shown in red for replicated SNPs. Recombination map showing how the signals are clearly demarcated by recombination hotspots. Nearby genes are shown in yellow.
See this image and copyright information in PMC

Comment in

References

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