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Comment
. 2007 Jun;71(12):1199-202.
doi: 10.1038/sj.ki.5002286.

Diabetic nephropathy and proximal tubule ROS: challenging our glomerulocentricity

S P Bagby  1
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Free article
Comment

Diabetic nephropathy and proximal tubule ROS: challenging our glomerulocentricity

S P Bagby. Kidney Int. 2007 Jun.
Free article

Abstract

Diabetic nephropathy is currently viewed as a predominantly glomerular process with glomerular injury driving secondary tubular loss. Brezniceanu and colleagues apply transgenic methods to support a prominent role for reactive oxygen species as mediators and for the proximal tubule as a major site of early disease activity in diabetes. Results support evidence for early tubular apoptosis and atrophy in human diabetic nephropathy.

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