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. 2007 Mar-Apr;26(2):67-9.

Role of magnification endoscopy in the diagnosis and evaluation of suspected celiac disease: correlation with histology

Rupa Banerjee  1 , Anuradha Shekharan, C Ramji, Srinivas R Puli, Rakesh Kalapala, Mohan Ramachandani, Rajesh Gupta, Sandeep Lakhtakia, Manu Tandan, G V Rao, D Nageshwar Reddy
Affiliations
  • PMID: 17558068

Role of magnification endoscopy in the diagnosis and evaluation of suspected celiac disease: correlation with histology

Rupa Banerjee et al. Indian J Gastroenterol. 2007 Mar-Apr.

Abstract

Background: Magnification endoscopy (ME), with 115-fold magnification, allows visualization of duodenal villi. We assessed the efficacy of ME for evaluation of villous atrophy.

Methods: ME and duodenal biopsy were done in 16 patients with suspected celiac disease and 16 control subjects undergoing endoscopy for reflux symptoms. The pathologist was unaware of the ME findings.

Results: Sensitivity, specificity and positive and negative predictive values for villous atrophy (partial or total) were 100%, 91%, 83% and 100%, respectively. Corresponding values for normal villous structure were 91%, 100%, 100% and 83%, respectively. There was significant concordance between the ME and histology findings.

Conclusion: ME is a reliable technique to diagnose villous atrophy.

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