PPARgamma and GLUT-4 expression as developmental regulators/markers for preadipocyte differentiation into an adipocyte
- PMID: 17560753
- DOI: 10.1016/j.domaniend.2007.05.001
PPARgamma and GLUT-4 expression as developmental regulators/markers for preadipocyte differentiation into an adipocyte
Abstract
In this document, we have integrated knowledge about two major cellular markers found in cells of the adipocyte lineage (an adipogenic marker and a metabolic marker). This review provides information as to how differentiation of a cell (such as an adipofibroblast, fibroblast or preadipocyte) to become a viable (and new) adipocyte is under different regulation than that experienced by an immature adipocyte that is just beginning to accumulate lipid. The differentiation, prior to lipid-filling, involves PPARgamma. Subsequently, lipid-filling of the adipocyte relies on a late subset of genes and, depending on depot specificity, involves GLUT-4 or any number of other metabolic markers.
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