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. 2007 Aug;51(8):2991-3.
doi: 10.1128/AAC.00225-07. Epub 2007 Jun 11.

Peroxide bond-dependent antiplasmodial specificity of artemisinin and OZ277 (RBx11160)

Marcel Kaiser  1 , Sergio Wittlin, Angela Nehrbass-Stuedli, Yuxiang Dong, Xiaofang Wang, Andrew Hemphill, Hugues Matile, Reto Brun, Jonathan L Vennerstrom
Affiliations

Peroxide bond-dependent antiplasmodial specificity of artemisinin and OZ277 (RBx11160)

Marcel Kaiser et al. Antimicrob Agents Chemother. 2007 Aug.

Abstract

Using nonperoxidic analogs of artemisinin and OZ277 (RBx11160), the strong in vitro antiplasmodial activities of the latter two compounds were shown to be peroxide bond dependent. In contrast, the weak activities of artemisinin and OZ277 against six other protozoan parasites were peroxide bond independent. These data support the iron-dependent artemisinin alkylation hypothesis.

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Figures

FIG. 1.
FIG. 1.
Structures of artemisinin, deoxyartemisinin, OZ277, and carbaOZ277.
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