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Case Reports
. 2007 Jun;64(6):886-9.
doi: 10.1001/archneur.64.6.886.

Manganese-induced Parkinsonism associated with methcathinone (Ephedrone) abuse

Rob M A de Bie  1 , Richard M Gladstone, Antonio P Strafella, Ji-Hyun Ko, Anthony E Lang
Affiliations
Case Reports

Manganese-induced Parkinsonism associated with methcathinone (Ephedrone) abuse

Rob M A de Bie et al. Arch Neurol. 2007 Jun.

Abstract

Background: Manganese intoxication may lead to a levodopa-resistant, akinetic-rigid syndrome. A new form of presumed manganese poisoning has been reported in drug-addicted persons from Russia, Ukraine, and Estonia who have intravenously injected self-prepared methcathinone hydrochloride (Ephedrone).

Patient: A 36-year-old man from Azerbaijan with hepatitis C and only modest hepatic synthetic dysfunction developed rapid-onset, levodopa-resistant parkinsonism with profound hypophonia.

Conclusion: Ephedronic encephalopathy outside the region of the former Soviet Union may become a more widespread public health problem as a result of global travel and the easy availability of the recipe for synthesis of methcathinone on the Internet.

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