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. 2007 Jun 13:6:15.
doi: 10.1186/1476-511X-6-15.

Ezetimibe is effective when added to maximally tolerated lipid lowering therapy in patients with HIV

Matthew T Bennett  1 , Kevin W Johns, Gregory P Bondy
Affiliations

Ezetimibe is effective when added to maximally tolerated lipid lowering therapy in patients with HIV

Matthew T Bennett et al. Lipids Health Dis. .

Abstract

To determine the efficacy and safety of adding ezetimibe to maximally tolerated lipid lowering therapy in patients with HIV dyslipidemia. Retrospective analysis of lipid parameters was conducted for 33 patients with HIV who had been prescribed ezetimibe 10 mg per day. Mean total cholesterol was reduced 21% (p < 0.001). Mean LDL was reduced 35% (p < 0.001). Mean HDL increased 8% (p = 0.038). Mean triglyceride was reduced 34% (p = 0.006). Mean Apolipoprotein B100 was reduced 33% (p = 0.043). No adverse events occurred. Ezetimibe appears safe and effective in patients with HIV when added to maximally tolerated doses of lipid lowering therapy.

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Figures

Figure 1
Figure 1
Ezetimibe add-on therapy: Effect according to baseline lipid agent * p < 0.05.
Figure 2
Figure 2
Ezetimibe add-on therapy: Percent of patients reaching targets for moderate risk according to baseline lipid agent.
See this image and copyright information in PMC

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