Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2007 Jun 13;27(24):6349-51.
doi: 10.1523/JNEUROSCI.1399-07.2007.

Transducin in rod photoreceptors: translocated when not terminated

Deepak Kalra  1 , Rebecca Elsaesser, Yi Gu, Kartik Venkatachalam
Affiliations
Review

Transducin in rod photoreceptors: translocated when not terminated

Deepak Kalra et al. J Neurosci. .
No abstract available

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Light-dependent translocation of transducin. Left, In dim light, RGS9-induced inactivation of transducin prevents its rapid dissociation from the membrane. Thus, most of the transducin remains in the OS of the rod cells. Right, In bright light, higher levels of activated transducin overwhelm the RGS9 complex, thereby allowing the accumulation of activated transducin. The latter dissociates from the membrane and subsequently translocates to the rod IS. Rh, Rhodopsin; hν, light; Pi, phosphate group.
See this image and copyright information in PMC

Comment on

References

    1. Fain GL. Why photoreceptors die (and why they don't) BioEssays. 2006;28:344–354. - PubMed
    1. Kerov V, Chen D, Moussaif M, Chen YJ, Chen CK, Artemyev NO. Transducin activation state controls its light-dependent translocation in rod photoreceptors. J Biol Chem. 2005;280:41069–41076. - PubMed
    1. Lee SJ, Montell C. Suppression of constant-light-induced blindness but not retinal degeneration by inhibition of the rhodopsin degradation pathway. Curr Biol. 2004;14:2076–2085. - PubMed
    1. Lee SJ, Xu H, Kang LW, Amzel LM, Montell C. Light adaptation through phospho-inositide-regulated translocation of Drosophila visual arrestin. Neuron. 2003;39:121–132. - PubMed
    1. Lobanova ES, Finkelstein S, Song H, Tsang SH, Chen CK, Sokolov M, Skiba NP, Arshavsky VY. Transducin translocation in rods is triggered by saturation of the GTPase-activating complex. J Neurosci. 2007;27:1151–1160. - PMC - PubMed

LinkOut - more resources