Comment
doi: 10.1038/sj.jid.5700774.
The regulation of permeability barrier homeostasis
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- PMID: 17568800
- DOI: 10.1038/sj.jid.5700774
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Comment
The regulation of permeability barrier homeostasis
J Invest Dermatol.
2007 Jul.
Free article
Abstract
Disruption of the permeability barrier stimulates a repair response that leads to the restoration of barrier function. Previous studies demonstrated that changes in ions, particularly calcium, and cytokines are positive signals, whereas serine protease activation of proteinase-activated receptor 2 is a negative signal regulating barrier recovery. Ikeyama and colleagues provide data that the nitric oxide signaling pathway also regulates barrier homeostasis.
Comment on
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Topical application of neuronal nitric oxide synthase inhibitor accelerates cutaneous barrier recovery and prevents epidermal hyperplasia induced by barrier disruption.J Invest Dermatol. 2007 Jul;127(7):1713-9. doi: 10.1038/sj.jid.5700742. Epub 2007 Mar 15. J Invest Dermatol. 2007. PMID: 17363920
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