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Comment
. 2007 Jul;127(7):1574-6.
doi: 10.1038/sj.jid.5700774.

The regulation of permeability barrier homeostasis

Kenneth R Feingold  1 , Matthias Schmuth, Peter M Elias
Affiliations
Free article
Comment

The regulation of permeability barrier homeostasis

Kenneth R Feingold et al. J Invest Dermatol. 2007 Jul.
Free article

Abstract

Disruption of the permeability barrier stimulates a repair response that leads to the restoration of barrier function. Previous studies demonstrated that changes in ions, particularly calcium, and cytokines are positive signals, whereas serine protease activation of proteinase-activated receptor 2 is a negative signal regulating barrier recovery. Ikeyama and colleagues provide data that the nitric oxide signaling pathway also regulates barrier homeostasis.

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