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. 2007 Dec;85(3):241-4.
doi: 10.1007/s11060-007-9416-1. Epub 2007 Jun 14.

No association of MDM2 SNP309 with risk of glioblastoma and prognosis

Soufiane El Hallani  1 , Yannick Marie, Ahmed Idbaih, Mathieu Rodero, Blandine Boisselier, Florence Laigle-Donadey, François Ducray, Jean-Yves Delattre, Marc Sanson
Affiliations

No association of MDM2 SNP309 with risk of glioblastoma and prognosis

Soufiane El Hallani et al. J Neurooncol. 2007 Dec.

Abstract

The MDM2 SNP309 variant has been shown to increase MDM2 expression and to be associated with tumor formation. In glioblastomas, the P53/MDM2 pathway is of crucial importance and MDM2 amplification is related to poor prognosis. However, we show here that MDM2 SNP309 is not associated with glioblastoma risk, and is not a prognostic factor.

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References

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