Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2007 May 28;13(20):2867-71.
doi: 10.3748/wjg.v13.i20.2867.

Expression of ornithine decarboxylase in precancerous and cancerous gastric lesions

Xin-Pu Miao  1 , Jian-Sheng Li, Hui-Yan Li, Shi-Ping Zeng, Ye Zhao, Jiang-Zheng Zeng
Affiliations

Expression of ornithine decarboxylase in precancerous and cancerous gastric lesions

Xin-Pu Miao et al. World J Gastroenterol. .

Abstract

Aim: To investigate the expression of ornithine decarboxylase (ODC) in precancerous and cancerous gastric lesions.

Methods: We studied the expression of ODC in gastric mucosa from patients with chronic superficial gastritis (CSG, n=32), chronic atrophic gastritis [CAG, n=43; 15 with and 28 without intestinal metaplasia (IM)], gastric dysplasia (DYS, n=11) and gastric cancer (GC, n=48) tissues using immunohistochemical staining. All 134 biopsy specimens of gastric mucosa were collected by gastroscopy.

Methods: The positive rate of ODC expression was 34.4%, 42.9%, 73.3%, 81.8% and 91.7% in cases with CSG, CAG without IM, CAG with IM, DYS and GC, respectively (P<0.01), The positive rate of ODC expression increased in the order of CSG < CAG (without IM) < CAG (with IM) < DYS and finally, GC. In addition, ODC positive immunostaining rate was lower in well-differentiated GC than in poorly-differentiated GC (P<0.05).

Conclusion: The expression of ODC is positively correlated with the degree of malignity of gastric mucosa and development of gastric lesions. This finding indicates that ODC may be used as a good biomarker in the screening and diagnosis of precancerous lesions.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Immunoreactivity of ODC protein in gastric precancerous and cancerous lesions. A: Immunostaining of ODC in CSG, SP × 200; B: Immunostaining of ODC in CAG (Without IM). SP ×200; C: Immunostaining of ODC in CAG (with IM) SP × 200; D: Immunostaining of ODC in DYS, SP × 200; E: Immunostaining of ODC in GC, SP × 200. CSG: chronic superficial gastritis; CAG: chronic atrophic gastritis; IM: intestinal metaplasia; DYS: dysplasia; GC: gastric cancer.
See this image and copyright information in PMC

References

    1. Thomas T, Thomas TJ. Polyamine metabolism and cancer. J Cell Mol Med. 2003;7:113–126. - PMC - PubMed
    1. Auvinen M, Paasinen A, Andersson LC, Hölttä E. Ornithine decarboxylase activity is critical for cell transformation. Nature. 1992;360:355–358. - PubMed
    1. Pegg AE. Polyamine metabolism and its importance in neoplastic growth and a target for chemotherapy. Cancer Res. 1988;48:759–774. - PubMed
    1. Tabib A, Bachrach U. Role of polyamines in mediating malignant transformation and oncogene expression. Int J Biochem Cell Biol. 1999;31:1289–1295. - PubMed
    1. O'Brien TG, Megosh LC, Gilliard G, Soler AP. Ornithine decarboxylase overexpression is a sufficient condition for tumor promotion in mouse skin. Cancer Res. 1997;57:2630–2637. - PubMed

Publication types

MeSH terms